An Innovative Approach to Understanding and Treating Cancer

  • Author : Tomas Koltai
  • Publsiher : Academic Press
  • Release : 15 February 2020
  • ISBN : 0128190590
  • Page : 320 pages
  • Rating : 4/5 from 21 voters

Download or read online book entitled An Innovative Approach to Understanding and Treating Cancer written by Tomas Koltai and published by Academic Press. This book was released on 15 February 2020 with total page 320 pages. Available in PDF, EPUB and Kindle. Get best books that you want by click Get Book Button and Read as many books as you like. Book Excerpt : The New pH-Centric Paradigm In Cancer Research: From Etiopathogenesis To New Therapeutic Avenues describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient, when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognised as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve either a stable disease or even regression with no toxicity. The book discusses topics such as lactic acid and its transport system in the pH paradigm; mechanisms to decrease extra cellular pH and increase intracellular pH; NHE-1 activity in cancer; carbonic anhydrases; vacuolar ATPase proton pump; and the sodium-bicarbonate cotransporter system. Additionally, it discusses complementary pharmacological interventions and cellular acidification and extracellular alkalinisation as a new and integral approach to cancer treatment. Analyzes thoroughly the mechanisms that lead to the inversion of pH gradient in cancer tissues Summarizes almost 100 years of research on pH inversion in cancer in one single source, discussing the most relevant and updated researches in the field Proposes new efficient treatments against cancer using pH inversion mechanisms, either with new drugs like proton transport inhibitors and proton pump inhibitors (PTIs and PPIs) as well as with repurposed drugs

An Innovative Approach to Understanding and Treating Cancer

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ISBN: 0128190590
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