Taxaceae and Cephalotaxaceae

  • Author : Da-Cheng Hao
  • Publsiher : Academic Press
  • Release : 01 February 2021
  • ISBN : 9780128239759
  • Page : 376 pages
  • Rating : 4/5 from 21 voters

Download or read online book entitled Taxaceae and Cephalotaxaceae written by Da-Cheng Hao and published by Academic Press. This book was released on 01 February 2021 with total page 376 pages. Available in PDF, EPUB and Kindle. Get best books that you want by click Get Book Button and Read as many books as you like. Book Excerpt : Taxus - a genus of coniferous trees or shrubs known as yews, in the family Taxaceae - is the source plant of anti-cancer drug Paclitaxel and its biosynthetic precursors, analogs and derivatives, and has been studied for decadesfor its pharmacological potential. There are many endemic Taxus species in China and internationally. Gaps are still present, however, in knowledge about the genomics, epigenomics, transcriptomics, proteomics, metabolomics and bioinformatics/cheminformatics of Taxaceae/Cephalotaxus and their associated microbes. In turn, systems biology and various omics technologies will take on a growing scientific role in the coming decades. Taxaceae and Cephalotaxaceae accounts for the biodiversity and chemodiversity of these medicinal plants, examining and synthesising existing research into their biology, chemistry and pharmacotherapy. The title examines how pharmacophylogeny allows sustainable conservation and exploitation, presents how these plants work from the chemical level upward, and examines associated microbe compounds, towards new chemical entity design and development for improved treatments. Six chapters present a summary of biological and biochemical research of Taxaceae plants; progress in mining their chemodiversity; mining pharmacotherapy utility from their chemodiversity and biodiversity; drug metabolism and pharmacokinetic diversity of their medicinal compounds; mining pharmacotherapy utility from associated microbes; the biodiversity, chemodiversity and pharmacotherapy of Cephalotaxus medicinal plants; and of Amentotaxus, Pseudotaxus and Torreya medicinal plants. The book envisages that multiple omics platforms and advanced systems biology will allow further exploration of Taxaceae and Cephalotaxaceae, streamlining the future drug supply chain. Pictures the biodiversity and chemodiversity of Taxaceae/Cephalotaxus medicinal plants Considers how a pharmacophylogeny framework can benefit conservation and sustainable exploitation of these plants Presents how Taxaceae/Cephalotaxus work from the chemical level upward Details the polypharmacology of these plants and associated microbe compounds in relation to pharmaceutical design and development Brings the reader up to date on the biology, chemistry and pharmacotherapy of Taxaceae/Cephalotaxus?medicinal plants

Taxaceae and Cephalotaxaceae

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Relase: 2021-02-01
ISBN: 9780128239759
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Taxaceae and Cephalotaxaceae

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